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Year : 2012  |  Volume : 1  |  Issue : 2  |  Page : 90-95

Effect of povidone-iodine washing of gastrointestinal mucosa or taking proton pump inhibitors on bacteremia after endoscopic ultrasonography-guided fine needle aspiration

1 Hospice Ward, Shengjing Hospital of China Medical University, Shenyang, China
2 Endoscopy Center, People's Hospital of Liaoning Province, Shenyang, China
3 Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang, China

Correspondence Address:
Siyu Sun
Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang
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Source of Support: None, Conflict of Interest: None

DOI: 10.7178/eus.02.007

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Objective: Few studies have evaluated the risk of bacteremia and infectious complications after endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Therefore, we aimed to study the frequency of bacteremia and search for a method to potentially reduce bacterial infection after EUS-FNA. We also investigated the effect of taking proton pump inhibitors (PPIs) before examination on the occurrence of bacteremia. Methods: A total of 28 healthy adult dogs were randomly assigned into three groups: control group, povidone-iodine group and omeprazole group. The dogs in the povidone-iodine group were administered with 0.5% povidone-iodine solution (10 mL) to wash gastrointestinal mucosa, while the dogs in the omeprazole group were fed with 20 mg omeprazole orally twice a day for 3 days before the EUS-FNA procedure. Blood samples were collected for cultures before EUS examination, between EUS and FNA, and 5 min, 15 min and 30 min after FNA. Results: There were 3 true-positive cases of bacteremia in the control group while there was 1 true-positive case of bacteremia in each of the two experiment groups. The differences in the occurrences of bacteremia between the control group and both experi­ment groups were not statistically significant. Conclusion: There are no statistically significant differences in the frequencies of bacteremia between the two experiment groups and the control group. Therefore, washing of the gastrointestinal mucosa with 0.5% povidone-iodine solution may not reduce the risk of bacterial infection and taking the PPIs does not increase the risk of bacteremia after EUS-FNA.

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