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ORIGINAL ARTICLE
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Accuracy and clinical outcomes of pancreatic EUS-guided fine-needle biopsy in a consecutive series of 852 specimens


1 Department of Pathology, Odense University Hospital; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
2 Department of Surgery, Upper GI and HPB Section, Odense University Hospital, Odense, Denmark
3 Department of Pathology, Odense University Hospital, Odense, Denmark
4 Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark; Department of Surgery, Upper GI and HPB Section, Odense University Hospital; Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark
5 Department of Pathology, Odense University Hospital; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark; Odense Pancreas Center (OPAC), Odense University Hospital, Odense, Denmark

Correspondence Address:
Sönke Detlefsen,
Department of Pathology, Odense University Hospital
Denmark
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/EUS-D-21-00180

Background and Objectives: Pancreatic EUS-guided fine needle biopsy (EUS-FNB) is increasingly used. Accuracy of EUS-FNB, particularly for benign diseases, utility of additional EUS-FNB if malignancy is suspected but initial diagnosis is inconclusive, and complication rate are not fully elucidated. We evaluated operating characteristics of EUS-FNB overall and for different diagnostic categories, value of additional EUS-FNB if malignancy is suspected but initial diagnosis is inconclusive, and frequency and type of complications. Methods: A retrospective tertiary single-center study including 852 consecutive pancreatic SharkCore EUS-FNBs from 723 patients between 2015 and 2020. EUS-FNB diagnoses were applied according to Papanicolaou Society's system and each category was further subcategorized. Results: Sufficient tissue cylinders for a histologic diagnosis were obtained in 93.4% (796/852). Accuracy was overall, for malignant, and benign entities 85.6% (confidence interval [CI]: 83.2%–87.9%), 88.3% (CI: 85.9%–90.4%), and 94% (CI: 92.2%–95.5%). Sensitivity and accuracy of EUS-FNB for autoimmune pancreatitis (AIP) (n = 15) was 83.3% (CI: 58.6%–96.4%) and 99.2% (CI: 98.3%–99.7%). Of patients in whom malignancy was suspected but initial EUS-FNB diagnosis was inconclusive, 7.3% (53/723) underwent one or two additional EUS-FNBs, and in 54.7% (29/53) of these, a malignant diagnosis was established. The frequency of hospitalization following EUS-FNB was 4.7%, with 0.2% (n = 2) incidents needing active intervention. Conclusions: We found a high accuracy of pancreatic EUS-FNB across all diagnostic categories including rare entities, such as AIP. In patients with a clinical suspicion of malignancy, additional EUS-FNB resulted in a conclusive diagnosis in more than half of cases. Complications necessitate hospitalization in almost 5%, but the majority are self-limiting.


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    -  Thomsen MM
    -  Larsen MH
    -  Di Caterino T
    -  Hedegaard Jensen G
    -  Mortensen MB
    -  Detlefsen S
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